肿瘤放疗 何泽来

姓   名：何泽来     性    别：男

出生年月：1982 年 02 月

专业技术职称：副教授/副主任医师

导师类别：硕导

电子邮箱：bybluesky@bbmu.edu.cn

1.  胸部肿瘤综合治疗

2.  抗肿瘤靶向纳米递送系统开发与研究

一、学习经历

2011.9—2014.7 ：上海交通大学肿瘤学博士研究生（在国家重点实验室）

2007.9—2010.7：苏州大学硕士研究生，影像医学与核医学专业

2001.9—2006.7 ：皖南医学院本科，临床医学专业

二、工作经历

2017.5—现在： 蚌埠医科大学第一附属医院肿瘤放疗科工作

2015.8—2017.4：温州医科大学附属第二医院肿瘤科医师

2014.8—2015.7：复旦大学附属肿瘤医院肿瘤科医师

2010.9—2011.8 ：浙江省嘉兴市妇幼保健院麻醉科医师

1.   蚌埠医科大学“揭榜挂帅”科研攻关项目，基于光热响应型 MXene@脂质体递送 IFN-β  miRNA  重 塑 肿瘤 微 环境 逆 转 NSCLC  耐 药 性 研 究 ， 编 号2025byjbgs034 ，2026.03 - 2028.02 ，10 万元，在研，主持。

2.   安徽省卫生健康科研重点项目，基于介孔硅的多模式载药体系联合 HFRT 靶向治疗三阴乳腺癌研究，编号 AHWJ2024Aa10062 ，2025.04 - 2028.03 ，40 万元，在研，主持。

3.   2019 年获蚌埠医学院“512 人才项目” 支持，编号 by51201314 ，经费 30 万。

4.   蚌埠市-蚌埠医学院联合创新项目，共载吉西他滨和姜黄素的纳米靶向递送系统治疗恶性肿瘤多发性骨转移研究，2019/01—2021/12 ，60 万，结题，主持。

5.   蚌埠医学院转化医学重点专项，立项编号 BYTM2019013 ，基于介孔硅多模式载药体系的生物相容性研究和联合放疗靶向治疗三阴乳腺癌初步探讨， 2019.10 -- 2021.09 ，5 万元，结题，主持。

6.   国家自然科学基金，项目批准号 81602727 ，共载顺铂和姜黄素的多功能纳米粒联合放疗靶向治疗肺癌脑转移研究，2017.1—2019.12，直接经费 17 万，结题，主持。

7.   温州市科技局项目，立项编号 Y20150049 ，两相释药纳米靶向递送系统逆转肺癌细胞耐药性研究，2015.7--2017.6 ，5 万，结题，主持。

代表性论文：

1.   Mingdong Ren#, Jie Tao#, Qiaoyu  Sun#,  Pengfei Li, Tianhao Liu, Zelai He*, Zhen Cui*. SEPT9 as a therapeutic target for enhancing radiotherapy efficacy in esophageal squamous cell carcinoma. Discover Oncology, 2026, 17: 217.

2.   Zhifei Huang#, Wenjia Peng#, Mengdie Zhao#, Bo Gao, Jing Qian, ShuangQiu Zhu, Tao Jiang, Mingdong Ren, Sulaiman Abdulahi Yusuf, Zelai He*, Hao Jiang*. Joint association of systemic inflammatory response index and sarcopenia with mortality among individuals with self-reported cancer. BMC Cancer, 2025, 25(1): 267.

3.   Jiaoyue  Qu#,  Yang   Liu#,  Yin  Yuan,   Zhao  Yu,   Jianming  Ding,  Zelai  He*, Gengming Wang*.  Impacts  of  sarcopenia  on  adverse  events  and  prognosis  in Chinese patients with esophageal cancer undergoing chemoradiotherapy. Frontiers in Nutrition, 2025, 12: 1523674.

4.   Tao Jiang#, Zhifei Huang#, Mingdong Reng#, Yuwei Ma, Bo Gao, Shilong Song, Fei Liu, Xiangyu Zhang, Jingwen Huang*, Zelai He*, Huijun Zhang*, Jing Ma*, Gengming  Wang*.  Integration  of  temperature-sensitive  hydrogels  loaded  with realgar and magnetic particles for lung cancer diagnosis and treatment. Cancer Nanotechnology, 2025, 16(1): 8.

5.   Lei Zhang, Yuqing Fan, Yuan Liu,  Bo  Gao,  Qiangkun Wan, Xiangyu Zhang*,

Zelai He*. CENPM drives prostate cancer progression via POC1A-mediated EMT activation. Biochemical and Biophysical Research Communications, 2025, 789: 152850.

6.   Yuwei  Ma#,  Tao  Jiang#,  Rong  Zhang,  Fei  Liu,  Shilong  Song,  Huijun  Zhang, Jingwen Huang*, Zelai He*. The Application of 2d Mxene Nanosheet -Based Thermosensitive Gel Delivery System Loaded with Cisplatin and Imiquimod for Lung Cancer. International Journal of Nanomedicine, 2024, 19: 4719-4733.

7.   Xiangyu  Zhang,  Zelai  He.  Cell  Membrane  Coated  pH-Responsive  Intelligent Bionic  Delivery  Nanoplatform  for  Active  Targeting  in  Photothermal  Therapy. International Journal of Nanomedicine, 2023, 18: 7729-7744.

8.   Hongbo Xu, Jingjing Liu, Yajun Zhang, Yan Zhou, Lei Zhang, Jia Kang, Can Ning, Zelai  He*,   Shilong   Song*.  KIF23,  under  regulation  by  androgen  receptor, contributes   to    nasopharyngeal   carcinoma    deterioration    by   activating    the Wnt/β-catenin signaling pathway. Functional & Integrative Genomics, 2023, 23(2): 116.

9.   Huijun Zhang, Ying Li, Xiaofeng Chen*, Zelai He*. Comparison of hook-wire and medical glue for CT-guided preoperative localization of pulmonary nodules. Front Oncol, 2022, 12: 922573.

10. Shilong  Song,  Hongbo  Xu,  Yan  Yang,   Qiangkun  Wan,   Bin   He,  Feng  Cai, Hongmei Yin, Yongchun Zhou, Xiaoxiao Jin, Zelai He. Assessing the Efficacy of a Tumor Nanovaccine and Artificial Antigen Presenting Cell-Based System as a Combination Therapy in a Mouse Model of Melanoma. Journal of Biomedical Nanotechnology, 2022, 18(5): 1362- 1375.

11. Zelai He#, Jia Liu#, Yuwei Ma#, Hao Jiang, Zhen Cui, Guowen Wang, Yufeng Wu, Jiuzhou Liu, Xixi Cai, Jing Qian, Jingwen Huang, Huijun Zhang, Hongwei Li. Anlotinib Combined with Cranial Radiotherapy for Non-Small Cell Lung Cancer Patients with Brain Metastasis: A Retrospectively, Control Study. Cancer Manag Res, 2021, 13: 6101-6111.

12. He Z, Zhang X, Zhang H, Cui Z, Sun L, Li H, Qian J, Ma J, Jiang H, Huang J. Nano-delivery vehicle based on chlorin E6, photodynamic therapy, doxorubicin

chemotherapy  provides  targeted  treatment   of  HER-2  negative,   ανβ3-positive breast cancer. Pharmacological Research, 2020, 160: 105184.

13. Zelai He, Huijun Zhang, Hongwei Li, Yanyan Wang, Jing Qian, Xixi Cai, Li Sun, Jingwen  Huang.  Preparation,  biosafety  and  cytotoxicity  studies  of  a  newly tumor-microenvironment-responsive       biodegradable        mesoporous        silica nano-system based on multi-modal and synergistic treatment. Oxidative Medicine and Cellular Longevity, 2020: 7152173.

14. Huijun Zhang, Ying Li, Nadier Yimin, Zelai He*, Xiaofeng Chen*. CT-guided hook-wire  localization  of  malignant   pulmonary   nodules  for  video   assisted thoracoscopic surgery. J Cardiothorac Surg, 2020, 15(1): 307.

15. Xiangyu  Zhang#,  Zelai  He#,  Longquan  Xiang,  Liang  Li,  Haiyan  Zhang, Fanzhong Lin, Hongying Cao. Codelivery of GRP78 siRNA and docetaxel via RGD-PEG-DSPE/DOPA/CaP      nanoparticles       for       the       treatment       of castration-resistant prostate cancer. Drug Design, Development and Therapy, 2019, 13: 1357 – 1372.

16. Qi Zhang#, Zelai He#, Gengming Wang, Hao Jiang#. Radiotherapy for recurrent central Giant cell granuloma: a case report. Radiation Oncology, 2019, 14: 130.

17. Qijun Jing#, Zelai He#, Hongbo Xu, Qian Sun, Gengming Wang, Yan Zhou, Hao Jiang#. Inhibitory effects of metastin on the migration and invasion of human nasopharyngeal    carcinoma    cells.    International    Journal     of   Clinical    and Experimental Medicine, 2019, 12(8): 10207 – 10216.

18. Huijun  Zhang, An  Wang,  Yulong  Tan,  Shaohua  Wang,  Qinyun  Ma,  Xiaofeng Chen*, Zelai He *. NCBP1 promotes the development of lung adenocarcinoma through upregulation of CUL4B. J Cell Mol Med, 2019, 23(10): 6965 – 6977.

19. Zelai  He *,  Huijun  Zhang*,  Zhen  Cui,  Qijun  Jing,  Zhe  Zhang,  Yong   Shen, Jingjing  Liu,  Jingwen  Huang.  A  case  of  chemorefractory  metastatic  type  AB thymoma sensitive to helical tomotherapy. Annals of translational medicine, 2019, 7(12): 274.

20. Zelai He, Ying Sun, Jun Cao, Yourong Duan. Degradation behavior and biosafety studies  of  the  mPEG-PLGA-PLL  copolymer.  Phys  Chem  Chem  Phys,  2016,

18(17): 11986 – 11999.

21. Zelai He, Ying Sun, Qi Wang, et al. Degradation and Bio-Safety Evaluation of mPEG-PLGA-PLL-Copolymer-Prepared   Nanoparticles.    Journal    of   Physical Chemistry C, 2015, 119: 3348 – 3362.

22. Zelai He, Qi Wang, Ying Sun, Ming  Shen, Mingjie Zhu, Malin Gu, Yi Wang, Yourong Duan. The biocompatibility evaluation of mPEG-PLGA-PLL copolymer and different LA/GA ratio effects for biocompatibility. Journal of Biomaterials Science, Polymer Edition, 2014, 25(9): 943 – 964.