肿瘤内科 钱峰
时间：[2026-06-24] 来源：
姓 名： 钱峰 性 别：男
出生年月： 1976 年 12 月
专业技术职称： 教授
导师类别： 博导
电子邮箱： fengqian@sjtu. edu.cn
1. 聚焦巨噬细胞极化分子机制，重点关注肺泡巨噬细胞等组织驻留 巨噬细胞的生理性和病理性功能，阐明泛素化修饰、能量代谢、转录 因子激活、磷酸化修饰等信号对于巨噬细胞的活化作用；
2. 聚焦感染性肺炎、过敏性哮喘、肺纤维化、 肺癌等呼吸系统疾病 的机制研究与药物靶标发现，揭示肺部炎症微环境调控呼吸系 统疾病的病理机制；
3. 聚焦恶性肿瘤的免疫机制与药物发现，揭示肿瘤相关巨噬细胞 （TAM）介导的炎症微环境调控肿瘤的病理机制；
4. 聚焦抗体药物研发体系和药物筛选体系 搭建，通过抗体制备技术、 细胞工程技术和高通量药物筛选技术研发创新药 物；
5. 建立新型肿瘤免疫、过敏性疾病、神经系统疾病、炎症性疾病、 消化系统疾病等新型疾病模型，用于体内药物筛选和药效学评价。
钱峰教授：男，博士，长聘教授，博士生导师。蚌埠医科大学学士和 硕士，南京大学博士，美国伊利诺伊州立大学药理学 系博士后、助理 教授，上海交通大学药学院分子药理学课题组组长。 主要研究方向为 免疫药理学和分子药理学；聚焦巨噬细胞极化和嗜中 性粒细胞活化的 分子机制；阐明呼吸系统疾病的病理机制；搭建疾病 动物模型，研发 创新药物。以通讯作者在 Nature Microbiology ， Nature Communication ， Journal of Experimental Medicine 等国际著名学术杂志上发表研究论 文 80 余篇。中国药理学会呼吸药理专业委员副主任委员 ，中国药理 学会抗炎免疫药理专业委员常务委员，上海市药学会 药理学专业委员 会副主任委员、理事，上海市药物代谢研究中心理事 ，上海市药物代 谢研究中心理事。主持国家自然科学基金面 上项目 7 项；国家重点研 发计划专项 2 项（分项目负责人 ）； 组建 3 个校企联合实验室和主持 企业横向项目 40 余项。担任科学出版社《 Pharmacology 》和《人民 卫生出版社中国医学教育题库》药理学学科副 主编。
1. 国家自然科学基金面上项目，编号 8257441 4 ，项 目名称：病毒感染 诱导肺泡巨噬细胞衰老累积 IL -1 α促进继发性肺纤维化 的机制研究 及潜在药靶发现， 2026/01-2029/12 ， 49 万，主持。
2. 国家自然科学基金面上项 目，编号 8237 3875 ，项 目名称： 受体 ChemR 23 通过 ATF 5 调控成纤维细胞极化介导特发性肺纤维化的机 制研究和潜在药靶鉴定， 2024/01-2027/12 ， 49 万，主持。
3. 国家重点研发计划，编号 2023YFA 0913700 ，项 目名称：抗体基因 簇克隆及人源化抗体应用研究， 2023/12-2028/11 ， 135 万，子项 目负 责人。
4. 国家自然科学基金面上项目，编号 82173821 ， 项 目名称： IL-33/ST2 诱导 FoxP 1 表达介导巨噬细胞耐受和继发性细菌性肺炎的 机制研究 及潜在药靶鉴定， 2022/01-2025/12 ， 55 万，主持。
5. 国家自然科学基金面上项目，编号 81973329 ，项 目名称： E3 泛素 连接酶 AMFR 调控巨噬细胞极化介导哮喘的作用机制 及潜在靶标研 究， 2020/01-2023/12 ， 55 万，主持。
6. 国家自然科学基金面上项目，编号 81773741 ，项 目名称：蛋白激酶 Akt 2 调控巨噬细胞介导特发性肺纤维化的机制研究与新型药 物靶标 鉴定， 2018/01-2021/12 ， 48 万，主持。
7. 国家重点研发计划“精准医学研究 ”，编号 2017YFC0908500 ，项 目 名 称： 搭 建 中 国人 群 头颈 部 恶 性肿 瘤个 性 化 PD X 平 台 ， 2017/01-2022/12 ， 210 万，子项 目负责人。
8. 国家自然科学基金面上项目，编号 81573438 ，项 目名称：蛋白激酶 p38MAPK 调控巨噬细胞极化在特发性肺纤维化中的作用机制研究， 2016/01-2019/12 ， 60 万，主持。
9. 国家自然科学基金面上项目，编号 81373424 ，项 目名称：蛋白激酶 MK 2 调控嗜中性粒细胞活化介导肝脏缺血再灌注 损伤机制与新型药 物靶标， 2014/01-2017/12 ， 80 万，主持。
代表性论文：
1. Determine the molecular mechanisms of macrophage polarization , with a particular emphasis on the physi ological and pathological fu nctions o f tissue-resident macrophages such as alveolar ma crophages. Elucidate the several signaling pathways , including ubiquitination modification , energy metabolism, transcription factor activation, and phos phorylation modification in macrophage s.
2. Focus on respiratory system diseases such as infectious pneumon ia, allergic asthma, pulmonary fibrosis, and lung cancer, revealing the pathological mechanisms of respiratory system diseases regu lated by the pulmonary inflammatory microenvironment .
3. the immune mechanisms and drug discovery of malignant tumors, revealing the pathological mechanisms of tumor regulation mediated by tumor-associated macrophages (TAM) in the inflammatory
microenvironment.
4. Focus on establishing the development system for antibody drugs and drug screening, utilizing antibody pr eparation technology, cell engineering technology, and high-throughput drug screening technology to develop innovative drug s.
5. Establish novel disease models for tumor immunity, aller gic diseases, neurological disorders, inflammatory diseases, and digestive system diseases , to be used for in vivo drug screening and pharmacological evaluation.
发表论文
以通讯作者发表的代表性研究论文（ Representative research papers published as corresponding author ）：
1.Mengkai Li, Tao Wang, Yuwen Zhong, Zhimin g Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, wei Gu, Zishu Wang, Lei Sun*, Feng Qian*. LMO7 Suppresses Tumor-Associated Macro phage Phagocytosis of Tumor Cells Through Degrad ation of LRP1. Adv Sci. 2025 Nov 9:e11162. doi: 10. 1002/advs.202511162. PMID: 41208232.
2.Xin-yi Yang, Ying Liu, Wen Li, Hui-xing Li, Yu-wen Zhong, Yu-han Cao, Tian-yi Liu, A-jing Xu, Wei Gu, Qing Liang, Feng Qian*, Lei Sun*. Serum amyloid A 3 aggravates bleomycin - induced pulmonary fibrosis through Krüppel-like factor 6-dependen t interlukin-36α expression. Acta Pharmacol Sin. 2025 Dec;46(12):3244-3256. doi: 10. 1038/s41401-025-01596-6. PMID: 40550960.
3.Lei Sun*, Hai-Bo Zhang, Hong-Chao Jiang, Wen L i, Meng-Kai Li, Xin-Yi Yang, Yuan-Yuan Cai, K e-Ke Xue, Yu-Sen Gou, Xin-Yue Liu, Qing Liang, Lu-Gen Zuo, Jian-Guo Hu*, Feng Qian*. LMO7 drives profibrotic fibroblast polarization and pulmonary fibrosis in mice through TGF-β signalling. Acta Pharm Sin 2025 Feb 25. doi:10. 1038/s41401-025-0148 8-9.
4.Haibo Zhang, Keke Xue, Wen Li, Xiny i Yang, Yusen Gou, Xiao Su, Feng Qian*, Lei Sun*. Cullin5 drives experimental asthma exacerbat ions
by modulating alveolar mac rophage antiviral immunity. Nature Communications, 2024, 15: 252.
5.Zhi-Ming Wang, Meng-Kai Li , Qing-Ling Yang, Shi-Xin Duan, Xin-Yi Lou, Xin-Yi Yang, Ying Liu, Yu-Wen Zhong, Yu Qiao, Zi-Shu Wang, Lei Sun *, Feng Qian *. Recombinant human adenovirus type 5 promotes anti-tumor immunity via in ducing pyroptosis in tumor endothelial cells. Acta Pharmacol Sin. 2024 Dec;45(12):2646-2656. doi: 10. 1038/s41401-024-0 1349-x.
6.Xin-Yue Liu, Jin-Chang Huang, Tao Zhang, Han-Rui W ang, Qi-Hui Xu, Yu-Gui Xia, A-Jing Xu, Ze-Yong Yang, Lei Sun, Wen-Ju an Zhao, Jun Zhao, Feng Qian*, Ai-Jun Hou*. Cyclo (L-Pro-L-Trp) from Chilobrachys jingzhao alleviates formalin-induced inflammatory pain by s uppressing the inflammatory response and inhibiting TRAF6- mediated MAPK and NF-κB signaling pathways. Int Immunopharmacol. 2024 Sep 30: 139: 112602. doi: 10. 1016/j.intimp.2024.112602.
7.Lei Sun, Haibo Zhang, Huihui Zhang, Xinyi Lou, Zhi ming Wang, Yaxian Wu, Xinyi Yang, Daijie Chen, Beining Guo, Ao Zhang, Feng Qian*. Intracellular Staphylococcus aureus utilizes endoplasmic reticulum-resident E3 ubiquitin ligase AMFR to promote pneumoni a via virulent -hemolysin B. Nature Microbiology. 2023, 8: 107
8.Shixin Duan, Xinyi Lou, Shiyi Chen, Hongcha o Jiang, Dongxin Chen, Rui Yin, Mengkai Li, Yuseng Gou, Wenjuan Zhao, Lei Sun*, Feng Qian*. Macrophage LMO 7 deficiency facilitates inflammatory injury via metabolic-epigenetic reprogramming. Acta Pharm Sin B. 2023, 12: 4785.
9.Huihui Zhang, Feng Qian*, Lei Sun*. Autocrine m otility factor receptor as a therapeutic target for asthm a: comments on 'AMFR drives allergic asthma development by promoting alveolar macrophage-derived GM-CSF production'. J Mol Cell Biol. 2022 Aug 26; 14(5): mjac032.
10.Huihui Zhang, Ran Wei, Xinyi Yang, Lu Xu, Hongcha o Jiang, Mengkai Li, Haixia Jiang, haibo Zhang, Zhihong Chen, Feng Qian *, Lei Sun *. AMFR drives allergic as thma development by promoting alveolar
macrophage-derived GM-CSF production. J Exp Med. 2 022 May 2;219(5): e20211828.
11.Dongxin Chen, Huiro ng Tang, Hongchao Jiang, Lei Sun, Wenjuan Zhao*, Feng Qian*. ACPA Alleviates Bleomycin-Induced Pulmonary Fibrosis by Inhibiting TGF-β-Smad 2/3 Signaling-Mediated Lung Fibroblast Activation. Front Pharmacol. 2022 Mar 9; 13: 835979.
12.Zhenghua Wu, Mengqi J ia, Wenjuan Zhao, Xucong Huang, Xinyi Yang, Dongxin Chen, Qiaolongbatu Xij ier, Xiaojing Li, Jiaqi Wu, Feng Qian*, Yuefen Lou*, Guo rong Fan*. Schisandrol A, the main active ingredient of Schisandrae Chinensis Fructus, inhibits pulmo nary fibrosis through suppression of the TGF -β signaling pathway as revealed by UPLC -Q- TOF / MS , network pharmacology and experimental verification . J Ethnopharmacol. 2022 May 10;289: 115031.
13.Hongchao Jiang, Yaxue Zhao, Huirong Tang, Shixin Du an, Mengkai Li, Xinyi Yang, Jingting Liu, Xinyi Lou, Yuanyuan Cai, Wenjuan Zhao, Lei Sun*, Feng Q ian *. Tetraethylthiuram disulphide alleviates pulmonary fibrosis through modulating transforming grow th factor-β signalling. Pharmacol Res. 2021 Dec; 174: 105923.
14.Ya-Xian Wu, Ying-Y ing Wang, Zhi-Qi Gao, Dan Chen, Gang Liu, Bin-Bin Wan, Feng-Juan Jiang , Ming-Xia Wei, Jing Zuo, Jun Zhu, Yong-Quan Chen, Feng Qian*, Qing-Feng Pang*. Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signa ling pathway. Acta Pharmacol Sin. 2021 Dec;42(12):2069.
15.Chen Zhengxu, Yang Xinyi, Zhang Lu, Li Man, Lei Sun, Feng Qian*. Celastrol alleviates LPS-induced inflammation in BMDMs and acute lung injury in mice via inhibition of p-38 MAPK/MK2 signa ling. European Journal of Inflammation. 2021; 19.
16.Xinyi Yang, Runsheng Li, Lu Xu, Fe ng Qian*, Lei Sun*. Serum amyloid A3 is required fo r caerulein-induced acute pancreatitis through
induction of RIP3-dependent necroptosis. Immunol Cell Biol. 2021 Jan;99(1): 34.
17.Hai-Feng Zhang, Hai-Bo Zhang, Xue-Ping Wu, Ya-Ling Guo, Wei-Dong Cheng, Feng Qian*. Fisetin alleviates sepsis-induc ed multiple organ dysfunction in mice via inhibiting p38 MAPK/MK2 signaling. Acta Pharmacol Sin. 2020 Oct;41(10): 13 48.
18.Tao Zhang, Junhang Jiang, Jingting Liu, Lu Xu, Shixin Duan, Lei Sun, Wenjuan Zhao, Feng Qian*. MK2 Is Required for Neutrophil-Derived ROS Production and Inflammatory Bowel Disease. Front Med(Lausanne). 2020 Jun 1 2;7: 207.
19.Qing Liang, Wuyang Cai, Yaxue Zhao, Huanb ai Xu, Huirong Tang, Daijie Chen, Feng Qian*, Lei Sun*. Ly corine ameliorates bleomycin - induced pulmonary fibrosis via inhibiting NLRP 3 inflammasome activation and pyroptosis. Pharmacol Re s. 2020 Aug;158: 104884.
20.Xingli Li, Chenxian Ye, Mubarak Mulati, Lei Sun*, Feng Qian*. Ellipticine blocks synergisti c effects of IL-17A and TNF-α in epithelial cells and alleviates severe acute pancreatitis-associated acute lung injury. Biochem Pharmacol. 2020 Jul; 177: 113992.
21.Jun Wang, Lei Sun, Yunjuan Nie, Shixin Duan, Tao Zhang, Weiwei Wang, Richard D Ye, Shangwei Hou, Feng Qian*. Protein K inase C δ ( PKC δ) Attenuates Bleomycin Induced Pulmonary Fibrosis via Inhibiting NF-κB Signaling Pathway. Front Physiol. 2020 Apr 22; 11: 367.
22.Zishu Wang, Kaikai Yu, Yudong Hu, Fang Su, Zhenyuan Gao, Ting Hu, Yang Yang, Xiangliao Cao, Feng Qian*. Schisantherin A induces cell apoptosis through ROS/JN K signaling pathway in human gastric cancer cells. Biochem Pharmacol. 2020 Mar;173: 113673.
23.Yunjuan Nie, Yudong Hu, Kaikai Yu, Dan Zhang, Yinze Shi, Yaolin Li, Lei Sun, Feng Qian*. Akt 1 regulates pulmonary fibrosis via modulati ng IL-13 expression in macrophages. Innate Immun. 2019 Oct;25(7 ): 451.
24.Li-Nian Huang, Lei Sun, Li-Ming Li u, Hui-Hui Zhang, Zhong-Bo Liang, Yan Rui, Jun-Feng Hu, Yong Zhang, John W Christman*, Feng Qian *. p38α MAP kinase promotes asthmatic inflammation through modulation of alternatively activated macrophages . J Mol Cell Biol . 2019 Dec 19; 11(12): 1095.
25.Yunjuan Nie, Dan Zhang, Feng Qian*, Yaxian Wu*. Baccatin III ameliorates bleomycin - induced pulmonary fibrosis via suppression of TGF-β1 production and TGF-β1-induced fibroblast differentiation. Int Immunopharmacol. 2019 Sep;74: 1056 96.
26.Rui Hao, Yunduan Song, Runs heng Li, Yaxian Wu, Xinyi Yang, Xiaozong Li, Feng Qian*, Richard D Ye*, Lei Sun*. MLN 4924 protects against interleukin-17A-induced pulmonary inflamm ation by disrupting ACT1-mediated signaling. Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6): L 1070.
27.Yun-Tian Chen, Yao Du, Bo Zhao, Li-Xing Gan, Kai-Kai Yu, Lei Sun*, Jian Wang*, Feng Qian*. Costunolide alleviates HKSA-induced acute lung injury via inhibition of ma crophage activation. Acta Pharmacol Sin. 2019 Aug;40(8): 1040.
28.Yunhe Ding, Yunduan Ding, Yaxian Wu, Huiqiong He, Ti anhong Yu, Yudong Hu, Depeng Zhang, Kaikai Yu, Xiaozong Li, Lei Sun, Fe ng Qian*. Isoalantolactone suppresses LPS-induced inflammation by inhibiting TRAF6 ubiquitination and alleviates acute lung injury . Acta Pharmacol Sin. 2019 Jan;40(1): 64.
29.Yaxian Wu, Huiqiong He, Sirui Liu, Yunhe Ding, Depeng Zhang, Dan Zhang, Lei Sun, Richard D. Ye, Feng Qian*. MK2 mediates macrophage activation and acute lung injury by regulating let-7e miRNA. Am J Physiol Lung Cell Mol Physiol. 201 8 Sep 1;315(3):L371-L381. doi: 10.1152/ajplung.00019.2018. Epub 2018 May 17. PMID: 29770701.
30.Depeng Zhang, Xiaozong Li, Yudong Hu, Hongcha o Jiang, Yaxian Wu, Yunhe Ding, Kaikai Yu, Huiqiong He, Jingsong Xu, Lei Sun, Fen g Qian*. Tabersonine attenuates lipopolysaccharide-induced acute lung injury via
suppressing TRAF 6 ubiquitination . Biochem Pharmacol . 2018 Aug;154: 183-192. doi: 10. 1016/j.bcp.2018.05.004. E pub 2018 May 7. PMID: 29746822.
31.Yunduan Song, Xiaozong Li, Yaxian Wu, Yao Shen, Fangfang Liu, Peipai Gao, Lei Sun, Feng Qian*. Emodin alleviates al ternatively activated macrophage and asthmatic airway inflammation in a murine asthma model. Acta Pharmacol Sin. 2018 Aug ;39(8): 1317-1325. doi: 10. 1038/aps.2017.147. Epub 2018 Feb 8. PMID: 29417945; PMCID: PMC6289379.
32.Yu Li, Depeng Zhang, Kaika i Yu, Yudong Hu, Qiong Wu, Feng Qian*, Zishu Wang*. CMPD1 inhibited human gastric cancer cell proliferat ion by inducing apoptosis and G2/M cell cycle arrest. Bio l Res. 2018 Apr 16;51(1): 11. doi: 10. 1186/s4065 9-018-0159-6. PMID: 29661232; PMCID: PMC5901880.
33.Yudong Hu, Kaikai Yu, Gang Wang, Depeng Zhang, Chaoji Shi,Yunhe Ding, Duo Hong, Dan Zh ang, Huiqiong He, Lei Sun, Jun-Nian Zheng*, Shuyang Sun*, Feng Qian*. Lanatoside C inhibits cell proliferation and induces apoptosis through attenuating Wnt/β-catenin/c-Myc signaling pathway in human gastric cancer cell.Biochem Pharmacol . 2018 Apr ;150:280- 292. doi: 10. 1016/j.bcp.2018.02.023. Epub 2018 Feb 21. PMID: 29475060.
34.Gufang Zhang, Jin Liu, Lehao Wu, Yu Fan, Lei Sun, Feng Qian, Daijie Chen, Richard D. Ye. Elevated Expression of Serum Amylo id A 3 Protects Colon Epithelium Against A cute Injury Through TLR2-Dependent Induction of Neutrophil IL-22 Expression in a Mouse Model of Colitis. Front Immunol. 2018 Jun 29;9: 1503. doi: 10.3389/fimmu.2018.01503. PMID: 30008720; PMCID: PMC603 3967.
35.Yi-Gong Guo, Yun-He Ding , Guo-Jing Wu, Sheng-lan Zhu, Yuan-Fang Sun, Shi-Kai Yan, Feng Qi an*, Hui-Zi Jin*, Wei-Dong Zhang*. Three new alkaloids from Xylopia vielana and their
antiinflammatory activities. Fitoterapia. 2018 Jun;127:96-100. doi:10. 1016/j.fitote.2018.02.001. Epub 2018 Feb 5. PMID: 294212 43.
36.Ya-xian Wu, Hui-qiong He, Yun-juan Nie, Yun-he Ding, Lei Sun ， Feng Qian*. Protostemonine effectively attenuates lipopolysaccharide-induced acute lung injury in mice. Acta Pharmacol Sin. 2018 Jan;39(1):85-96. doi: 10. 1038/aps.2017.131. Epub 2017 Oc t 19. PMID: 29047459; PMCID: PMC5758663.
37.Hui-qiong He, Ya-xian Wu, Yun-juan N ie, Jun Wang, Mei Ge, Feng Qian*. LYRM03, an ubenimex derivative, attenuat es LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pat hway. Acta Pharmacol Sin. 2017 Mar;38 (3):342-350. doi: 10. 1038/aps.2016.141. Epub 2017 Jan 23. PMID: 28112185; PMC ID: PMC5342666.
38.Shu-Qin Li, Ning Su, Ping Gong, Hai-Bo Zhang, Jin Liu, Ding Wang, Yan-Ping Sun, Yan Zhang, Feng Qian, Bo Zhao, Yang Yu, and Richard D. Ye. The Expression of Formyl Peptide Receptor 1 is Correlated with Tumor Invasion of Human Colorectal Cancer. Sci Rep. 2017 Jul 19;7(1):5918. doi: 10. 1038/s41598-017-06368-9. PMID: 28724995; PMCID: PMC5517416.
39.Ziyan Zhu, Lei Sun, Rui Hao, Hongchao Jiang, Fen g Qian*, Richard D. Ye*. Nedd8 modification of Cullin-5 regulateslipopolysaccharide-induced acute lung injury. Am J Physiol Lu ng Cell Mol Physiol. 2017 Jul 1;313(1):L104-L 114. doi:10.1152/ajplung.00410.2016. Epub 2017 May 18. PMID: 28522566.
40.Yunjuan Nie, Lei Sun, Yaoyao Yang, Jun Wang, Huiqiong He, Yanhua Chang, Yaxian Wu, Qing Liang, Yudong Hu, Jianwei Zhu, Richard D. Ye, John W. Christman, Feng Qian*. AKT2 Regulates Pulmonary Inflammation and Fibrosis via Modulating Macrophage Activation . J Immunol. 2017 Jun 1; 198(11):4470-4 480. doi: 10.4049/jimmunol.1601503. Epub 2017 Apr 28. PMID: 2 8455433.
41.Qing Liang, Ni Cheng, Gufang Zhang, Yurong Liang, Feng Qian, Dianqing Wu, Richard D. Ye. Identification o f P-Rex1 as an
anti-inflammatory and anti-fibrogenic target for pulmonary fibrosis. Sci Rep. 2016 May 13;6:25785. doi: 10. 1038/srep25785. P MID: 27173636; PMCID: PMC4865757.
42.Sangwoon Chung, Tae Jin Lee, Brenda F. Reader, Ji Young Kim, Yong Gyu Lee, Gye Young Park, Manjula Karpurapu, Megan N. Ballinger,Feng Qian, Luiza Rusu, Hae Young Chung, Terry G. Unterman, Carlo M. Croce and John W. Christman. FoxO1 r egulates allergic asthmatic inflammation through regulating polarization of the macrophage inflammatory phenotype. Oncotarget. 2016 Apr 5;7(14): 1753 2-46. doi: 10. 18632/oncotarget.8162. PMID: 27007158; PMCID: PMC4951231.
43.Feng Qian*, Jing Deng, Ga ng Wang, Richard D. Ye, John W. Christman . Pivotal Role of Mitogen - Activated Protein Kinase - Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases . Curr Protein Pept Sci. 2016; 17(4):332-42. doi: 10.2174/1389203716666150629121324.PMID: 26119506; PMCID: PMC4878395.
44.Yao-yao Yang, Hui-qiong He, Jia-hua Cui , Yun-juan Nie, Ya-xian Wu, Rui Wang, Richard D. Ye, Qiong Wu, Shao-shun Li and Feng Qian*. Shikonin Derivative DMAKO -05 Inhibits Akt Signal Activation and Melanoma Proliferation . Chem Biol Drug Des. 2016 Jun;87(6):895-904. doi: 10. 1111/cbdd.12722. Epub 2016 Feb 18 . PMID: 26804061.
45.Feng Qian*, Jing Deng, Yong Gyu Lee, Jimmy Zhu, Manjula Karpurapu, Sangwoon Chung, Jun-Nian Z heng, Lei Xiao, Gye Young Park, and John W. Christman. The transcription f actor PU.1 promotes alternative macrophage polarization and asthmatic airway inflammatio n. J Mol Cell Biol. 2015 Dec;7(6):557-67. doi: 10. 1093/jmcb/mjv042. Epub 2015 Jun 22. PMID: 26101328; PMC ID: PMC4664118.
46.Bo Shen, Brian Estevez, Zheng Xu, Barry Kreutz, Andre i Karginov, Yanyan Bai, Feng Qian, Urao Norifumi, Deane Mosher, Xia oping Du*. The interaction of Gα13 with integrin β1 mediates cell migration by dynamic regulation of RhoA . Mol Biol Cell . 2015 Oct 15;26(20):3658 -70.
doi: 10. 1091/mbc.E 15-05-0274. Epub 2015 Aug 26. P MID: 26310447;
PMCID: PMC4603935.
47.Shu-Qin Li, Yang Yu, Jin-Zhao Han, Ding Wang, Jin Liu, Feng Qian, Guo-Huang Fan, Richard Bucala, Ri chard D. Ye*. Deficiency of macrophage migration inhibitory factor attenuates tau hyperphosphorylation in mouse models of Alzheimer ' s disease . J Neuroinflammation. 2015 Sep 17;12:177. doi: 10. 1186/s12974-015-03 96-3. PMID: 26382037; PMCID: PMC4574615.
48.Xiaowen Liu, Tao Yang, Koya Suzuki, Sachiko Tsukita, Masar u Ishii, Shuping Zhou, Gang Wang, Luyang Cao, Feng Qian, Shalina Taylor, Myung-jin Oh, Irena Levitan, Richard D. Y, Graeme K. Carnegi e, Yong Zhao , Asrar Malik , Jingsong Xu *. Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient. J Exp Med . 2015 Feb 9;212(2):267-80. doi: 10. 1084/jem.20140508. Epub 2015 Jan 19. PMID: 25601651; PMCID: PMC432 2047.
49.Yong Gyu Lee, Jong Jin Jeon g, Sharmilee Nyenhuis, Evgeny Berdyshev, Sangwoon Chung, Ravi Ranjan, Manjula Karpurapu, Ji ng Deng, Feng Qian, Elizabeth A.B. Kelly, Nizar N. Jarjour, S teven J. Ackerman, Viswanathan Natarajan, Jo hn W Christman, and Gye Young Park*. Recruited alveola r macrophages, in response to airway epithelial-derived monocyte chemoattractant protein 1/C Cl2, regulate airway inflammation and remodeling in allergic asthma. Am J Respir Cell Mol Biol. 2015 Jun;52(6):772-84. doi: 10.1165/rcmb.2014-0255OC. PMID: 25360868; PMCID : PMC4491131.
50.Mingjie Chen, Huibing Zhou, Ni Cheng, Feng Qian, Ri chard D. Ye*. Serum amyloid A 1 isoforms display different efficacy at To ll-like receptor 2 and formyl peptide receptor 2. Immunobiolog y. 2014 Dec;219(12):916-23. doi: 10. 1016/j.imbio.2014 .08.002. Epub 2014 Aug 10. PMID: 25154907; PMCID: PMC42527 04.
51.Hong Yin, Alesander Zakharov, Weidong Xu, Adam Corken, Alexander Zakharov, Feng Qian, Sasha Pavlovic, Alekasandar Krbanjevic,
Alexander Lyubimov, Zaijie J. Wang, Xi aoping Du*. Role for platelet glycoprotein Ib-IX and ef fects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality. Arterioscler Throm b Vasc Biol. 2013 Nov;33(11):2529-37. doi: 10. 1161/ATVBAHA.113.302339. Epub 2013 Sep 19. PMID: 24051142; PMCI D: PMC4043446.
52.Ram Naikawadi, Ni Cheng, S tephen M. Vogel, Feng Qian, Dianqing Wu, Asrar B. Malik, Richard D Ye*. A critical role for phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 in endothelial junction disruption and vascular hyperpermeability . Circ Res . 2012 Dec 7;111(12): 1517-27. doi: 10. 11 61/CIRCRESAHA.112.273078. Epub 2012 Sep 10. PMID: 22965143; PMCID: PMC3677960.
53.Benjamin N Gantner, Huali Jin, Feng Qian, Nissim Hay, Bin He, Richard D Ye*. The Akt 1 isoform is required f or optimal IFN-β transcription through direct phosphorylation of β-catenin . J Immunol . 2012 Sep 15;189(6):3104-1 1. doi: 10.4049/jimmunol.1201669. Epub 2012 Aug 17. PMID: 22904301; PMCID: PMC3658160.
54.Feng Qian*, Jing Deng, Benjamin N. Gantner, Chen Dong, John W. Christman, Richard D Ye*. Map kinase phosphatase 5 prote cts against sepsis-induced acute lung injury. Am J Physiol Lung C ell Mol Physiol. 2012 May 1;302(9):L866-74. doi: 10.1152/ajplung.00277.2011. Epub 2012 Feb 3. PMID: 22307906; PMCID: PMC33 62165.
55.Feng Qian, Guy C. Le Breton, Jia Chen, Jing Deng, John W. Christman, Dianqing Wu, Richard D. Ye*. Role f or the guanine nucleotide exchange factor phosphatidylinositol-3,4,5-t risphosphate-dependent rac exchanger 1 in platelet secretion and aggregation. Arterioscler T hromb Vasc Biol. 2012 Mar;32(3):768-77. doi: 10. 1161/ATVBAHA.1 11.243675. Epub 2011 Dec 29. PMID: 22207728; PMCID: PMC3288658.
56.Jing Deng, Xuerong Wang, Feng Qian, Stephen M. Voge l, Lei Xiao, Ravi Ranjan, Hyesuk Park, Manjula Karpurapu, Richard D. Ye, Gye Young Park, John W*. Christman. Protective ro le of reactive oxygen
species in endotoxin-induced lung inflam mation through modulation of IL-10 expression. J Immunol . 2012 Jun 1; 188(11):5734-40. doi: 10.4049/jimmunol.11013 23. Epub 2012 Apr 30. PMID: 22547702; PMCID: PMC3358534.
57.Anke Di, Xiao-Pei Gao, Feng Qian, T akeshi Kawamura, Jin Han, Claudie Hecquet, Richard D. Ye, Stephen M. Vogel, Asrar B. Malik*. The redox - sensitive cation channel TRPM 2 modulates phagocyte ROS production and inflammation. Nat Immunol. 2011 Nov 20; 13(1):29 -34. doi: 10. 1038/ni.2171. PMID: 22101731; PMCID: PMC3 242890.
58.Yuqing Chen, Dianming Li, H ongli Liu, Huanbai Xu, Honghua Zheng, Feng Qian, Wei Li, Chengling Zhao, Zhenhua Wang, Xiaojing Wang*. Notch-1 signaling facilitates surv ivin expression in human non-small cell lung cancer cells. Cancer Biol Ther. 2011 Jan 1; 11(1): 14-21. doi: 10.4161/cbt.11.1.13730. Epub 2011 Jan 1. PMID: 20962575.
59.Min Ren, Qing Guo, Liang Gu o, Martin Lenz, Feng Qian, Rory R. Koenen, Hua Xu, Alexander B. Schilling, Christian Weber, Richard D. Ye, Aaron R. Dinner, Wei-Jen Tang*. Polymerization of MIP-1 chem okine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme. EMBO J. 2010 Dec 1;29(23):3952-66. doi: 10. 1 038/emboj.2010.256. Epub 2010 Oct 19. PMID: 20959807; PMCID: PMC3020635.
60.Feng Qian, Jing Deng, Ni Cheng, Emily J. Welch, Yongliang Zhang, Asrar B. Malik, Richard A. Flavell, Chen Dong, Richa rd D. Ye. A non - redundant role for MKP 5 in limiting ROS production and preventing LPS-induced vascular injury. EMBO J. 2009 Oct 7;28(19):2 896-907. doi: 10. 1038/emboj.2009.234. Epub 2009 Aug 20. PMID: 19696743; PMCID: PMC2760111.
61.Ran Song, Feng Qian, Yu-Pei Li, Xia Sheng , Shao-Xian Cao, Qiang Xu *. Phosphatase of regenerating liver -3 localizes to cyto - membrane and is required for B 16F 1 melanoma cell metastasis in vitro and in vivo. PLoS One. 2009;4(2):e4450. doi: 10 .1371/journal.pone.0004450. Epub 2009 Feb 13. PMID: 19214 221; PMCID: PMC2635958.
62.Feng Qian, Yu-Pei Li, Xia Sheng, Zi-Chao Zhang, Ran Son g, Wei Dong, Shao-Xian Cao, Zi-Chun Hua, Qiang Xu. PRL-3 si RNA inhibits the metastasis of B 16-BL6 mouse melanoma cells in vitro and in vivo. Mol Med. 2007 Mar-Apr; 13(3-4): 151-9. doi: 10.2119/2006–00076.Qian. Erratum in: Mol Med. 2007 May-Jun;13(5-6):325. PMID: 17592549; PMCID: PMC1892759.
63.Jianming Guo, Feng Qian, J ianxin Li, Qiang Xu, Ting Chen*. Identification of a new metabolite of astilbin , 3'-O- methylastilbin , and its immunosuppressive activity against contact dermatitis. Clin Chem. 20 07 Mar;53(3):465-71. doi: 10.1373/clinchem.2006.077297. Epub 2007 Feb 1. Erratum in: Clin Che m. 2007 May;53(5):997. PMID: 17272490.
64.Yang Sun, Jianli Liu, Feng Qian, Qiang Xu*. Nitric oxide inhibits T cell adhesion and migration by down-regulation of beta1-integrin expression in immunologically liver - injured mice . Int Immunopharmacol . 2006 Apr;6(4):616-26. doi: 10. 1016/j.intimp.2005.09.015. Epub 2005 Oct 25. PMID: 16504925.
65.Feng Qian, Zi-Chao Zhang, Xue-F eng Wu, Yu-Pei Li, Qiang Xu*. Interaction between integrin alpha (5) and fibronectin is required for metastasis of B 16F 10 melanoma cells . Biochem Biophys Res Commun. 2005 Aug 12;333(4): 1269-75. doi: 10. 10 16/j.bbrc.2005.06.039. PMID: 15979576.
专著及教材：
1. 担任《人民卫生出版社中国医学教育题 库》药理学学科副主编 专利：
1. 发明人：钱峰，王军，段世鑫，专利名称：针对 IL-33 的抗体，专 利号： 202010521408.9 。
2. 发明人：钱峰，王军，专利名称：一种与 IL-33 相关疾病的新型的抗原表位肽及其应用，专利号： 201910036482.9 。
3. 发明人：钱峰，王军，专利名称：一种抗体及其应用，专利号： 201910037214.9 。
4. 发明人：钱峰，俞凯凯，孙树洋，吴穷，张志愿，孙磊，王军，顾 子悦，胡玉冬，专利名称：一种抗人 CD47 单克隆抗体的制备及其应 用，专利号： 201811350763.3 。
5. 发明人：钱峰，何慧琼，吴亚先。，专利名称：原百部 碱在制备抗 哮喘药物中的用途，专利号： 201510868643.2 。
上一条：肿瘤内科 苏方
下一条：肿瘤内科 高振远
【关闭窗口 】
