2. 蚌埠医科大学“揭榜挂帅”科研攻关项 目，2025byjbgs070 ，Neddylation-CRL1 轴介导头颈鳞癌免疫逃逸的机制研究，2026/03-2028/03 ，5 万元，主持
3. 蚌埠医科大学科技计划项 目， 2024byzd076 ，EFTUD2 作为头颈鳞癌免疫治疗靶点联合ICB 治疗策略研究，2025/03-2027/03，5 万元，主持
4.蚌埠医科大学第一附属医院第三批杰出青年科学基金项 目，2025byyfyjq05，SMARCA5 通过 JAK2/STAT1/PD-L1 通路促进 CD8+ T 细胞介导的 HNSCC 抗肿瘤免疫应答，2025 /10- 2029/9 ，50 万元，主持
四、代表性成果 (论文
专利
专著等)
代表性论文：
(1) Liu W*, Ding Z*, Tao Y*, Liu S*, Jiang M, Yi F, Wang Z, Han Y, Zong H, Li D, Zhu Y, Xie Z, Sang S, Chen X, Miao M, Chen X, Lin W, Zhao Y, Zheng G, Zafereo M, Li G, Wu J#, Zha X#, Liu Y# . A positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression. Mol Cancer. 2024 Jul 9;23(1):141.
(2) Ding Z*, HanY*, Liu W*, Zhang W*, Xie Z, Zhou P, Jiang S, Lu J, Li J, Li Y, Ji M, Xue H, Tang J, Wang Z, Xia K, Li D, Wu J, Wang Y, Kim LM, Naseem DF, Li G, Zafereo ME, Yao C#, Tao Y#, Zha X#, Liu Y# . TRAPPC4 Promotes GPX4 Stability to Drive Ferroptosis Resistance and Tumor Progression in Head and Neck Squamous Cell Carcinoma. Cancer Res. 2026 Apr 13.
(3) Liu S*, Zhang W*, Liu W*, Ding Z*, Zhang R, Han Y, Niu Z, Zhang M, Li H, Li D, Wang Z, Peng J, Wu Y, Han Y, Xie Z, Wu J, Qin L, Hu Z, Chen X, Hu Y, Liu Y#, Ma S#, Zha X# . PRMT1- Mediated SWI/SNF Complex Recruitment via SMARCC1 Drives IGF2BP2 Transcription to Enhance Carboplatin Resistance in Head and Neck Squamous Cell Carcinoma. Adv Sci (Weinh). 2025 Jun;12(22): e2417460.
(4) Zhu Y*, Ma C*, Zhong L, Wang T, Liu W#, Wang Z# . From lipid modification to cell death: the diverse roles ofS-palmitoylation in cell fate decisions. Cell Commun Signal. 2026 Apr 11;24(1):318.
(5) Wang Z*, Zong H*, Liu W*, Lin W*, Sun A, Ding Z, Chen X, Wan X, Liu Y, Hu Z, Zhang H, Li H, Liu Y, Li D#, Zhang S#, Zha X# . Augmented ERO1α upon mTORC1 activation induces ferroptosis resistance and tumor progression via upregulation of SLC7A11. J Exp Clin Cancer Res. 2024 Apr 13;43(1):112.
